REAL-TIME PCR-BASED ASSAY TO QUANTIFY THE RELATIVE AMOUNT OF HUMAN AND MOUSE TISSUE PRESENT IN TUMOR XENOGRAFTS

Real-time PCR-based assay to quantify the relative amount of human and mouse tissue present in tumor xenografts

Abstract Background Xenograft samples used to test anti-cancer drug efficacies and toxicities in vivo contain an unknown mix of mouse and human cells.Evaluation of drug activity can be confounded by samples containing large amounts of contaminating mouse tissue.We have developed a real-time quantitative polymerase chain reaction (qPCR) assay using

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Using an Internal State Variable Model Framework to Investigate the Influence of Microstructure and Mechanical Properties on Ballistic Performance of Steel Alloys

An internal state variable (ISV)-based constitutive model has been used within a Lagrangian finite element analysis (FEA) framework to simulate ballistic impact of monolithic rolled Label Console Window homogenous armor (RHA) steel plates by RHA steel spheres and cylinders.The ISV model predictions demonstrate good agreement with experimental impac

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